During the 2,830 at-bats in his career, Santander has hit .246 with 695 base hits. His on-base percentage is .307 and he holds a career OPS of .776. He has accumulated 383 runs in addition to having earned 435 runs batted in. Santander has recorded a walk 226 times while fanning on 644 occasions. He has gone yard 155 times, with 1,327 bases in total and also a .469 slugging percentage.
Santander has recorded 140 base knocks out of 595 at-bats for an average at the plate of .235. He has taken a base 58 times and has accounted for an on-base percentage of .308. Over the course of the season, Santander has compiled 91 runs, accrued 102 runs batted in and has hit 44 home runs. He has recorded an OPS of 0.814 in addition to a slugging percentage of .506. He has struck out 129 times while compiling 301 total bases.
| Year | Team | BA | HR | H | BB | R | RBI | OBP | PA | AB | OPS | OPS+ | 2B | 3B | G | SLG | SB | CS | TB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Career | .246 | 155 | 695 | 226 | 383 | 435 | .307 | 3,115 | 2,830 | .776 | N/A | 155 | 6 | 746 | .469 | 10 | 7 | 1,327 | 644 | |
| 2024 | BAL | 129.000 | 2 | 91 | 0 | 595 | 44 | .235 | 155 | 665 | .506 | 1 | 140 | 25 | 3 | .308 | 102 | 2 | 134 | 58 |
| 2023 | BAL | .257 | 28 | 152 | 55 | 81 | 95 | .325 | 656 | 591 | .797 | 121 | 41 | 1 | 153 | .472 | 5 | 1 | 279 | 152 |
| 2022 | BAL | .240 | 33 | 138 | 55 | 78 | 89 | .318 | 647 | 574 | .773 | 117 | 24 | 0 | 152 | .455 | 0 | 2 | 261 | 122 |
| 2021 | BAL | .241 | 18 | 98 | 23 | 54 | 50 | .286 | 438 | 406 | .720 | 92 | 24 | 0 | 110 | .433 | 1 | 1 | 176 | 101 |
| 2020 | BAL | .261 | 11 | 40 | 10 | 24 | 32 | .315 | 165 | 153 | .890 | 135 | 13 | 1 | 37 | .575 | 0 | 1 | 88 | 25 |
| 2019 | BAL | .261 | 20 | 99 | 19 | 46 | 59 | .297 | 405 | 380 | .773 | 100 | 20 | 1 | 93 | .476 | 1 | 2 | 181 | 86 |
| 2018 | BAL | .198 | 1 | 20 | 6 | 8 | 6 | .250 | 108 | 101 | .547 | 51 | 5 | 1 | 33 | .297 | 1 | 0 | 30 | 21 |
| 2017 | BAL | .267 | 0 | 8 | 0 | 1 | 2 | .258 | 31 | 30 | .625 | 67 | 3 | 0 | 13 | .367 | 0 | 0 | 11 | 8 |
