Santana has compiled an average at the plate of .242 for his time in baseball with 1,058 scored runs and an OPS of .785. Over the course of his time in the league, he approached the plate 8,780 times and has delivered with a base hit 1,789 times. His slugging percentage is .431 and he has accumulated 3,188 bases. In his career, Santana has drilled 324 baseballs out of the park while knocking in 1,082 runs. He has struck out 1,449 times and has been walked on 1,278 attempts at the plate, which has contributed to a .354 on-base percentage.
Santana is sitting with 219 bases in total with 124 hits in 521 at-bats. He has compiled an OBP of .328 with 65 walks and 99 strikeouts. Since the beginning of the campaign, Carlos Santana has batted in 71 runs and also is sitting with a slugging percentage of .420. He has scored 63 runs this year and has knocked 23 balls over the fence. He has recorded a batting average when batting of .238 while holding an OPS of .749.
| Year | Team | BA | HR | H | BB | R | RBI | OBP | PA | AB | OPS | OPS+ | 2B | 3B | G | SLG | SB | CS | TB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Career | .242 | 324 | 1,789 | 1,278 | 1,058 | 1,082 | .354 | 8,780 | 7,400 | .785 | N/A | 393 | 17 | 2,080 | .431 | 58 | 18 | 3,188 | 1,449 | |
| 2024 | MIN | 99.000 | 0 | 63 | 0 | 521 | 23 | .238 | 150 | 594 | .420 | 1 | 124 | 26 | 3 | .328 | 71 | 4 | 109 | 65 |
| 2023 | TOT | .240 | 23 | 132 | 65 | 78 | 86 | .318 | 619 | 550 | .747 | 104 | 33 | 1 | 146 | .429 | 6 | 0 | 236 | 104 |
| 2022 | TOT | .202 | 19 | 87 | 71 | 52 | 60 | .316 | 506 | 431 | .692 | 100 | 18 | 0 | 131 | .376 | 0 | 0 | 162 | 88 |
| 2022 | SEA | .192 | 15 | 49 | 35 | 35 | 39 | .293 | 294 | 255 | .693 | 101 | 8 | 0 | 79 | .400 | 0 | 0 | 102 | 60 |
| 2022 | KCR | .216 | 4 | 38 | 36 | 17 | 21 | .349 | 212 | 176 | .690 | 97 | 10 | 0 | 52 | .341 | 0 | 0 | 60 | 28 |
| 2021 | KCR | .214 | 19 | 121 | 86 | 66 | 69 | .319 | 659 | 565 | .660 | 79 | 15 | 0 | 158 | .342 | 2 | 0 | 193 | 102 |
| 2020 | CLE | .199 | 8 | 41 | 47 | 34 | 30 | .349 | 255 | 206 | .699 | 93 | 7 | 0 | 60 | .350 | 0 | 0 | 72 | 43 |
| 2019 | CLE | .281 | 34 | 161 | 108 | 110 | 93 | .397 | 686 | 573 | .911 | 136 | 30 | 1 | 158 | .515 | 4 | 0 | 295 | 108 |
| 2018 | PHI | .229 | 24 | 128 | 110 | 82 | 86 | .352 | 679 | 560 | .766 | 105 | 28 | 2 | 161 | .414 | 2 | 1 | 232 | 93 |
| 2017 | CLE | .259 | 23 | 148 | 88 | 90 | 79 | .363 | 667 | 571 | .818 | 112 | 37 | 3 | 154 | .455 | 5 | 1 | 260 | 94 |
| 2016 | CLE | .259 | 34 | 151 | 99 | 89 | 87 | .366 | 688 | 582 | .865 | 123 | 31 | 3 | 158 | .498 | 5 | 2 | 290 | 99 |
| 2015 | CLE | .231 | 19 | 127 | 108 | 72 | 85 | .357 | 666 | 550 | .752 | 102 | 29 | 2 | 154 | .395 | 11 | 3 | 217 | 122 |
| 2014 | CLE | .231 | 27 | 125 | 113 | 68 | 85 | .365 | 660 | 541 | .792 | 122 | 25 | 0 | 152 | .427 | 5 | 2 | 231 | 124 |
| 2013 | CLE | .268 | 20 | 145 | 93 | 75 | 74 | .377 | 642 | 541 | .832 | 135 | 39 | 1 | 154 | .455 | 3 | 1 | 246 | 110 |
| 2012 | CLE | .252 | 18 | 128 | 91 | 72 | 76 | .365 | 609 | 507 | .785 | 121 | 27 | 2 | 143 | .420 | 3 | 5 | 213 | 101 |
| 2011 | CLE | .239 | 27 | 132 | 97 | 84 | 79 | .351 | 658 | 552 | .808 | 126 | 35 | 2 | 155 | .457 | 5 | 3 | 252 | 133 |
| 2010 | CLE | .260 | 6 | 39 | 37 | 23 | 22 | .401 | 192 | 150 | .868 | 143 | 13 | 0 | 46 | .467 | 3 | 0 | 70 | 29 |
