During his NFL career, Clayton caught 84 receiving touchdowns. His catches per contest and yards per outing average were 4.2 and 64.6 yards. He earned a total of 8,974 yards with an average of 15.4 yards per reception. His percentage of passes caught sat at 418.7% and he earned that by catching 582 out of the 139 passes that were attempted. Mark Clayton played in 139 contests throughout his career.