In the 7,400 at-bats in his career, Santana has compiled an average at the plate of .242 with 1,789 base hits. He has gone deep 324 times, in addition to having 3,188 total bases and also a .431 slugging percentage. Santana has earned a walk 1,278 times while being called out on strikes on 1,449 attempts. He has accrued 1,058 runs and also has 1,082 RBIs. His OBP comes in at .354 and he also has a career OPS of .785.
Santana has recorded 124 hits in 521 AB’s for an average at the plate of .238. He has earned a walk 65 times and has accumulated an on-base percentage of .328. On the campaign, Santana has tallied 63 runs, recorded 71 RBI and has hit 23 home runs. He has amassed an OPS of 0.749 with a slugging percentage of .420. He has gone down swinging 99 times while accruing 219 total bases.
| Year | Team | BA | HR | H | BB | R | RBI | OBP | PA | AB | OPS | OPS+ | 2B | 3B | G | SLG | SB | CS | TB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Career | .242 | 324 | 1,789 | 1,278 | 1,058 | 1,082 | .354 | 8,780 | 7,400 | .785 | N/A | 393 | 17 | 2,080 | .431 | 58 | 18 | 3,188 | 1,449 | |
| 2024 | MIN | 99.000 | 0 | 63 | 0 | 521 | 23 | .238 | 150 | 594 | .420 | 1 | 124 | 26 | 3 | .328 | 71 | 4 | 109 | 65 |
| 2023 | TOT | .240 | 23 | 132 | 65 | 78 | 86 | .318 | 619 | 550 | .747 | 104 | 33 | 1 | 146 | .429 | 6 | 0 | 236 | 104 |
| 2022 | TOT | .202 | 19 | 87 | 71 | 52 | 60 | .316 | 506 | 431 | .692 | 100 | 18 | 0 | 131 | .376 | 0 | 0 | 162 | 88 |
| 2022 | SEA | .192 | 15 | 49 | 35 | 35 | 39 | .293 | 294 | 255 | .693 | 101 | 8 | 0 | 79 | .400 | 0 | 0 | 102 | 60 |
| 2022 | KCR | .216 | 4 | 38 | 36 | 17 | 21 | .349 | 212 | 176 | .690 | 97 | 10 | 0 | 52 | .341 | 0 | 0 | 60 | 28 |
| 2021 | KCR | .214 | 19 | 121 | 86 | 66 | 69 | .319 | 659 | 565 | .660 | 79 | 15 | 0 | 158 | .342 | 2 | 0 | 193 | 102 |
| 2020 | CLE | .199 | 8 | 41 | 47 | 34 | 30 | .349 | 255 | 206 | .699 | 93 | 7 | 0 | 60 | .350 | 0 | 0 | 72 | 43 |
| 2019 | CLE | .281 | 34 | 161 | 108 | 110 | 93 | .397 | 686 | 573 | .911 | 136 | 30 | 1 | 158 | .515 | 4 | 0 | 295 | 108 |
| 2018 | PHI | .229 | 24 | 128 | 110 | 82 | 86 | .352 | 679 | 560 | .766 | 105 | 28 | 2 | 161 | .414 | 2 | 1 | 232 | 93 |
| 2017 | CLE | .259 | 23 | 148 | 88 | 90 | 79 | .363 | 667 | 571 | .818 | 112 | 37 | 3 | 154 | .455 | 5 | 1 | 260 | 94 |
| 2016 | CLE | .259 | 34 | 151 | 99 | 89 | 87 | .366 | 688 | 582 | .865 | 123 | 31 | 3 | 158 | .498 | 5 | 2 | 290 | 99 |
| 2015 | CLE | .231 | 19 | 127 | 108 | 72 | 85 | .357 | 666 | 550 | .752 | 102 | 29 | 2 | 154 | .395 | 11 | 3 | 217 | 122 |
| 2014 | CLE | .231 | 27 | 125 | 113 | 68 | 85 | .365 | 660 | 541 | .792 | 122 | 25 | 0 | 152 | .427 | 5 | 2 | 231 | 124 |
| 2013 | CLE | .268 | 20 | 145 | 93 | 75 | 74 | .377 | 642 | 541 | .832 | 135 | 39 | 1 | 154 | .455 | 3 | 1 | 246 | 110 |
| 2012 | CLE | .252 | 18 | 128 | 91 | 72 | 76 | .365 | 609 | 507 | .785 | 121 | 27 | 2 | 143 | .420 | 3 | 5 | 213 | 101 |
| 2011 | CLE | .239 | 27 | 132 | 97 | 84 | 79 | .351 | 658 | 552 | .808 | 126 | 35 | 2 | 155 | .457 | 5 | 3 | 252 | 133 |
| 2010 | CLE | .260 | 6 | 39 | 37 | 23 | 22 | .401 | 192 | 150 | .868 | 143 | 13 | 0 | 46 | .467 | 3 | 0 | 70 | 29 |
