Over the course of the 7,423 at-bats in his career, Santana has hit .242 and has racked up 1,795 base hits. He has gone deep 324 times, with 3,196 bases in total and also a .431 slugging percentage. Santana has tallied a free base 1,280 times while fanning on 1,452 chances. He has tallied 1,062 runs in addition to having 1,083 runs batted in. His on-base percentage is .354 and he has earned a lifetime OPS of .784.