During his NFL career, Holmes grabbed 36 touchdowns. His catches per contest and yards per contest average were 0.5 and 8.2 yards. He tallied 6,030 yards and had an average of 15.5 yards per reception. His catch percentage sat at 53.0% and he earned that by hauling in 389 out of the 734 passes that were attempted. Santonio Holmes took the field in 734 games for his career.